With the ScreenChip System, researchers can rapidly generate and collect precise whole-animal data to assess neuronal and physiological responses to genetic mutations, drug effects and other environmental changes.
See data published by the users in the areas of neurodegenerative diseases, sleep deprivation, virus infection, aging and drug development.
Electrophysiological measures of aging pharynx function in C. elegans reveal enhanced organ functionality in older, long-lived mutants. J.Russell, N. Burnaevskiy, B. Ma, M. Mailig, F. Faust, M. Crane, M. Kaeberlein, A. Mendenhall. The Journals of Gerontology: Series A, Nov. 2017.
Tool-Driven Advances in Neuropeptide Research from a Nematode Parasite Perspective. CJ McCoy, LE Atkinson, E Robb, NJ Marks, AG Maule, A Mousley. Trends Parasitol. 2017 Dec;33(12):986-1002. doi: 10.1016/j.pt.2017.08.009. Epub 2017 Oct 3.
Rabies virus modifies host behaviour through a snake-toxin like region of its glycoprotein that inhibits neurotransmitter receptors in the CNS. K. Hueffer, S. Khatri, S. Rideout, M. Harris, R. Papke, C. Stokes & M. Schulte. Nature Scientific Reports 7, Article number: 12818 (2017)
Distinct unfolded protein responses mitigate or mediate effects of nonlethal deprivation of C. elegans sleep in different tissues. J. Sanders, M. Scholz, I, Merutka and D. Biron. BMC Biology 2017 15:67.
Precision deletion of the entire coding sequence of the mod-5 locus causes increase in pharyngeal pumping frequency. T. Brock, S. Pop, C. Bradford, J. Lawson, L. Resch, C. Hopkins. Micropublication:biology. June 2017.
Basal pharyngeal pumping elevated in C. elegans mod-5 mutants. T. Hiebert, A. Chicas-Cruz, and K. McCormick. Micropublication:biology. June 2017.
Reduced pharyngeal pumping rates observed in tph-1 mutants using microfluidic electropharyngeogram (EPG) recordings. T. Hiebert, A. Chicas-Cruz, and K. McCormick. Micropublication:biology. Feb. 2017.
Mutations in KCNQ potassium channels cause pharyngeal pumping defects in C. elegans. Y. Clovis, A. Webb, C. Turner, and W. Roberts. Micropublication:biology. Nov. 2016.
Trehalose Extends Healthspan in C. elegans. K. Robinson and K. McCormick. Micropublication:biology. Oct. 2016.
Publications Using Other Microfluidic Platforms
Microfluidic EPG Recordings Show Striking Pharyngeal Pumping Phenotype in a C. elegans Alzheimer’s Disease Model. J. Weeks, K. Robinson, B. Wanjeri, P. Copenhaver, W. Roberts. Micropublication:biology. Oct. 2016.
Microfluidic platform for electrophysiological recordings from host-stage hookworm and Ascaris suum larvae: A new tool for anthelmintic research. J. Weeks, W. Roberts, K. Robinson, M. Keaney, J. Vermeire, J. Urban, Jr., S. Lockery and J. Hawdon. Int J Parasitol Drugs Drug Resist. 2016 Dec; 6(3): 314–328. doi: 10.1016/j.ijpddr.2016.08.001.
A microfluidic device for whole-animal drug screening using electrophysiological measures in the nematode C. elegans. S. Lockery, S. Hulme, W. Roberts, K. Robinson, A. Laromaine, T. Lindsay, G. Whitesides, and J. Weeks. Lab Chip. 2012 Jun 21; 12(12): 2211–2220. doi: 10.1039/c2lc00001f.