See data published by the researchers in the areas of neurodegenerative diseases, sleep deprivation, virus infection, aging and drug development using our custom C. elegans and zebrafish and the ScreenChip System.
Knockout
Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity. Woo JA, Liu T, Trotter C, Fang CC, De Narvaez E, LePochat P, Maslar D, Bukhari A, Zhao X, Deonarine A, Westerheide SD, Kang DE. Nat Commun. 2017 Jun 6;8:15558.
MosSCI
Mixtures of chemical pollutants at European legislation safety concentrations: how safe are they? Carvalho, RN; Arukwe, A; Ait-Aissa, S; Bado-Nilles, A; Balzamo, S; Baun, A; Belkin, S; Blaha, L; Brion, F; Conti, D; Creusot, N; Essig, Y; Ferrero, VE; Flander-Putrle, V; Fürhacker, M; Grillari-Voglauer, R; Hogstrand, C; Jonáš, A; Kharlyngdoh, JB; Loos, R; Lundebye, AK; Modig, C; Olsson, PE; Pillai, S; Polak, N; Potalivo, M; Sanchez, W; Schifferli, A; Schirmer, K; Sforzini, S; Stürzenbaum, SR; Søfteland, L; Turk, V; Viarengo, A; Werner, I; Yagur-Kroll, S; Zounková, R; Lettieri, T. Toxicol Sci. 2014 Sep;141(1):218-33.
Plastin increases cortical connectivity to facilitate robust polarization and timely cytokinesis. Ding, WY; Ong, HT; Hara, Y; Wongsantichon, J; Toyama, Y; Robinson, RC; Nédélec, F; Zaidel-Bar, R. J Cell Biol. 2017 May 1;216(5):1371-1386.
The secreted MSP domain of C. elegans VAPB homolog VPR-1 patterns the adult striated muscle mitochondrial reticulum via SMN-1. Schultz, J; Lee, SJ; Cole, T; Hoang, HD; Vibbert, J; Cottee, PA; Miller, MA; Han, SM. Development. 2017 Jun 15;144(12):2175-2186.
MED GATA factors promote robust development of the C. elegans endoderm. Maduro, MF; Broitman-Maduro, G; Choi, H; Carranza, F; Wu, AC; Rifkin, SA. Dev Biol. 2015 Aug 1;404(1):66-79.
The 14-3-3 protein PAR-5 regulates the asymmetric localization of the LET-99 spindle positioning protein. Wu, JC; Espiritu, EB; Rose, LS. Dev Biol. 2016 Apr 15;412(2):288-297.
Expression of human Bcl-xL (Ser49) and (Ser62) mutants in Caenorhabditis elegans causes germline defects and aneuploidy. Baruah, PS; Beauchemin, M; Parker, JA; Bertrand, R. PLoS One. 2017 May 8;12(5):e0177413.
Longevity Genes Revealed by Integrative Analysis of Isoform-Specific daf-16/FoxO Mutants of Caenorhabditis elegans. Chen, AT; Guo, C;Itani, OA; Budaitis, BG; Williams, TW; Hopkins, CE; McEachin, RC; Pande, M;Grant, AR; Yoshina, S; Mitani, S; Hu, PJ. Genetics. 2015 Oct;201(2):613-29.
Matefin/SUN-1 Phosphorylation on Serine 43 Is Mediated by CDK-1 and Required for Its Localization to Centrosomes and Normal Mitosis in C. elegans Embryos. Zuela, N; Gruenbaum, Y. Cells. 2016 Feb 24;5(1).
Point Mutation
NALCN channelopathies: Distinguishing gain-of-function and loss-of-function mutations. Bend, EG; Si, Y; Stevenson, DA; Bayrak-Toydemir, P; Newcomb, TM; Jorgensen, EM; Swoboda, KJ. Neurology. 2016 Sep 13;87(11):1131-9.
An RNAi-based suppressor screen identifies interactors of the Myt1 ortholog of Caenorhabditis elegans. Allen, AK; Nesmith, JE; Golden, A. G3 (Bethesda). 2014 Oct 8;4(12):2329-43.
LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during cytokinesis. HONG, Y; Sonneville, R; Wang, B; Scheidt, V; Meier, B; Woglar, A; Demetriou, S; Labib, K; Jantsch, V; Gartner, A. Nat Commun. 2018 Feb 20;9(1):728.
Tagging
CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis. Sonneville, R; Moreno, SP; Knebel, A; Johnson, C; Hastie, CJ; Gartner, A; Gambus, A; Labib, K. Nat Cell Biol. 2017 May;19(5):468-479.
Olfactory stem cells reveal MOCOS as a new player in autism spectrum disorders. Féron, F; Gepner, B; Lacassagne, E; Stephan, D; Mesnage, B; Blanchard, MP; Boulanger, N; Tardif, C; Devèze, A; Rousseau, S; Suzuki, K; Izpisua Belmonte, JC; Khrestchatisky, M; Nivet, E; Erard-Garcia, M. Mol Psychiatry. 2016 Sep;21(9):1215-24.
Ribonuclease-Mediated Control of Body Fat. Habacher, C; Guo, Y; Venz, R; Kumari, P; Neagu, A; Gaidatzis, D; Harvald, EB; Færgeman, NJ; Gut, H; Ciosk, R. Dev Cell. 2016 Nov 7;39(3):359-369.
Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs. Piazzesi, A; Papić, D; Bertan, F; Salomoni, P; Nicotera, P; Bano, D. Cell Rep. 2016 Oct 18;17(4):987-996.
The C. elegans VAPB homolog VPR-1 is a permissive signal for gonad development. Cottee, PA; Cole, T; Schultz, J; Hoang, HD; Vibbert, J; Han, SM; Miller, MA. Development. 2017 Jun 15;144(12):2187-2199.
Mechanism of biofilm-mediated stress resistance and lifespan extension in C. elegans. Smolentseva, O; Gusarov, I; Gautier, L; Shamovsky, I; DeFrancesco, AS; Losick, R; Nudler, E. Sci Rep. 2017 Aug 2;7(1):7137.
Regulation of DJ-1 by Glutaredoxin 1 in Vivo: Implications for Parkinson’s Disease. Johnson, WM; Golczak, M; Choe, K; Curran, PL; Miller, OG; Yao, C; Wang, W; Lin, J; Milkovic, NM; Ray, A; Ravindranath, V; Zhu, X; Wilson, MA; Wilson-Delfosse, AL; Chen, SG; Mieyal, JJ. Biochemistry. 2016 Aug 16;55(32):4519-32.
Caenorhabditis elegans BUB-3 and SAN-1/MAD3 Spindle Assembly Checkpoint Components Are Required for Genome Stability in Response to Treatment with Ionizing Radiation. Bertolini, S;Wang, B;Meier, B;Hong, Y;Gartner, A. G3 (Bethesda). 2017 Dec 4;7(12):3875-3885.
A Bystander Mechanism Explains the Specific Phenotype of a Broadly Expressed Misfolded Protein. Klabonski, L;Zha, J;Senthilkumar, L;Gidalevitz, T. PLoS Genet. 2016 Dec 7;12(12):e1006450.
A Differentiation Transcription Factor Establishes Muscle-Specific Proteostasis in Caenorhabditis elegans. Bar-Lavan, Y; Shemesh, N; Dror, S; Ofir, R; Yeger-Lotem, E; Ben-Zvi, A. PLoS Genet. 2016 Dec 30;12(12):e1006531.
The nphp-2 and arl-13 genetic modules interact to regulate ciliogenesis and ciliary microtubule patterning in C. elegans. Warburton-Pitt, SR; Silva, M; Nguyen, KC; Hall, DH; Barr, MM. PLoS Genet. 2014 Dec 11;10(12):e1004866.
Knockout
Eyes shut homolog is required for maintaining the ciliary pocket and survival of photoreceptors in zebrafish. Yu, M; Liu, Y; Li, J; Natale, BN; Cao, S; Wang, D; Amack, JD; Hu, H. Biol Open. 2016 Nov 15;5(11):1662-1673.
Electrophysiological measures of aging pharynx function in C. elegans reveal enhanced organ functionality in older, long-lived mutants. J. Russell, N. Burnaevskiy, B. Ma, M. Mailig, F. Faust, M. Crane, M. Kaeberlein, A. Mendenhall. The Journals of Gerontology: Series A, Nov. 2017.
Tool-Driven Advances in Neuropeptide Research from a Nematode Parasite Perspective. CJ McCoy, LE Atkinson, E Robb, NJ Marks, AG Maule, A Mousley. Trends Parasitol. 2017 Dec;33(12):986-1002. doi: 10.1016/j.pt.2017.08.009. Epub 2017 Oct 3.
Rabies virus modifies host behaviour through a snake-toxin like region of its glycoprotein that inhibits neurotransmitter receptors in the CNS. K. Hueffer, S. Khatri, S. Rideout, M. Harris, R. Papke, C. Stokes & M. Schulte. Nature Scientific Reports 7, Article number: 12818 (2017)
Distinct unfolded protein responses mitigate or mediate effects of nonlethal deprivation of C. elegans sleep in different tissues. J. Sanders, M. Scholz, I, Merutka and D. Biron. BMC Biology 2017 15:67.
Precision deletion of the entire coding sequence of the mod-5 locus causes increase in pharyngeal pumping frequency. T. Brock, S. Pop, C. Bradford, J. Lawson, L. Resch, C. Hopkins. Micropublication:biology. June 2017.
Basal pharyngeal pumping elevated in C. elegans mod-5 mutants. T. Hiebert, A. Chicas-Cruz, and K. McCormick. Micropublication:biology. June 2017.
Reduced pharyngeal pumping rates observed in tph-1 mutants using microfluidic electropharyngeogram (EPG) recordings. T. Hiebert, A. Chicas-Cruz, and K. McCormick. Micropublication:biology. Feb. 2017.
Mutations in KCNQ potassium channels cause pharyngeal pumping defects in C. elegans. Y. Clovis, A. Webb, C. Turner, and W. Roberts. Micropublication:biology. Nov. 2016.
Trehalose Extends Healthspan in C. elegans. K. Robinson and K. McCormick. Micropublication:biology. Oct. 2016.
Microfluidic EPG Recordings Show Striking Pharyngeal Pumping Phenotype in a C. elegans Alzheimer’s Disease Model. J. Weeks, K. Robinson, B. Wanjeri, P. Copenhaver, W. Roberts. Micropublication:biology. Oct. 2016.
Microfluidic platform for electrophysiological recordings from host-stage hookworm and Ascaris suum larvae: A new tool for anthelmintic research. J. Weeks, W. Roberts, K. Robinson, M. Keaney, J. Vermeire, J. Urban, Jr., S. Lockery and J. Hawdon. Int J Parasitol Drugs Drug Resist. 2016 Dec; 6(3): 314–328. doi: 10.1016/j.ijpddr.2016.08.001.
A microfluidic device for whole-animal drug screening using electrophysiological measures in the nematode C. elegans. S. Lockery, S. Hulme, W. Roberts, K. Robinson, A. Laromaine, T. Lindsay, G. Whitesides, and J. Weeks. Lab Chip. 2012 Jun 21; 12(12): 2211–2220. doi: 10.1039/c2lc00001f.
