Drug resistance in many pathogens — viruses, bacteria, protozoa, parasitic worms and more — presents a growing and potentially catastrophic challenge to human and animal health. Resistance is manifested by a decreased ability, or complete failure, of previously-effective drugs to successfully prevent or clear infections. Well-known human examples include methicillin-resistant Staphylococcus aureas (MRSA); multi-drug resistant […]
Our CSO revisits his Veritas Genomic Sequencing report for a closer look at how significant some of the discovered variants are
NemaMetrix is the market leader for early preclinical in-vivo testing using small animal models to gain a better understanding of the efficacy, mode of action, toxicity and potential targets for novel compounds. In this case study we outline how we used the animal model C. elegans to perform a set of specific experiments designed by our experts to provide rapid and reliable data based on our customer’s priorities. Using the data that we provided, our customer was able to apply for multiple patents in a timely manner.
The introduction of engineered site-specific DNA endonucleases has brought precise genome editing in many model organisms into the realm of possibility. Thanks to precise and efficient genome editing in zebrafish using the CRISPR/Cas9 system, scientists at NemaMetrix are using zebrafish for rapid genetic analysis. Utilizing morphants and crispants you can…
We reviewed a recent article that discusses the best techniques available for C. elegans transgenics, as well as experimental concerns that should be considered.