Serotonin is well known for being important in the regulation of people’s mood. We found that we can model the serotonin biochemical pathway using a sensitive measure for pharyngeal pumping in C. elegans.
C. elegans’ feeding behavior strongly influences the worm’s aging and longevity. We tested adult worms to quantify how aging affects their feeding behavior. In older adults, pharyngeal pumping was weaker and less regular.
Nemametrix Inc., a life sciences startup that created the innovative ScreenChip System for drug screening, mutant phenotyping, and toxicological assessment, has entered into a marketing partnership with Knudra Transgenics, a genome engineering company specializing in custom built transgenic model organisms for research and drug discovery.
The NemaMetrix ScreenChip system was developed for C. elegans, which is but one of the estimated 1 million members of the highly diverse phylum, Nematoda. To demonstrate the utility of microfluidic EPG recordings from species beyond C. elegans, we adapted the platform to record from several human and animal gastrointestinal parasites, male and female members of a dioecious nematode species, and a carnivorous nematode.
The heavy metal, copper (Cu2+), is toxic to humans and C. elegans. We used the ScreenChip system to detect Cu2+ in aqueous samples at concentrations (≤10 mg/L) within the range found in contaminated home water supplies. EPG recordings provide a powerful new tool for C. elegans toxicology research.