The Precise Deletion service uses CRISPR/Cas9 genome editing to remove a small defined region of DNA. This can be useful for deleting protein domains, DNA regulatory regions, or any other sequence of your choice.
Deletions can also be performed in coding regions for functional analysis of protein domains or to isolating isoform function. Transcription binding sites or introns can be deleted to reveal information about gene regulation.
Service Details (price reflects academic pricing)
|Service Package||Price||Est. Delivery Time|
|Full Build||$4,075 - $4,360||6 - 8 Weeks|
|Candidate Lines||$2,554 - $2,839||3 - 4 Weeks|
|Custom Injection Mix||$995 - $1,295||1 - 2 Weeks|
Precise Deletion Publications
A Role in Apoptosis Regulation for the rad-51 Gene of Caenorhabditis elegans. Germoglio M, Adamo A. Genetics. 2018 Aug;209(4):1017-1028.
WAH-1/AIF regulates mitochondrial oxidative phosphorylation in the nematode Caenorhabditis elegans. Troulinaki K, Büttner S, Marsal Cots A, Maida S, Meyer K, Bertan F, Gioran A, Piazzesi A, Fornarelli A, Nicotera P, Bano D. Cell Death Discov. 2018 Jan 29;4:2.