In 2017, a now-redacted paper published in Nature Methods claimed that CRISPR created hundreds of unintended mutations in mouse models, and that algorithms designed to detect those “off target effects” weren’t working. The news sent share prices of CRISPR-based companies plummeting, and created rumblings—even panic—among scientists and gene editing-watchers worldwide. How accurate was CRISPR-Cas9, after all?
In 1998, the soil nematode Caenorhabditis elegans became the first multicellular organism of which the genome has been sequenced completely. One surprising result of this approach was that ~65% of the human disease genes have a counterpart in the worm….
Researching chemicals that may cause damage to the nervous system is very challenging—of the 1,000 known toxic chemicals, only a dozen have been found to be toxic, but many unknowns exist. While mammal models remain the primary selection of research labs looking at the effects of metals and certain organic molecules on the brain—especially the […]
Humanized model organisms are powerful biological models that allow scientists to study human disease genes in simpler contexts without losing the value of in vivo studies. In either C. elegans or Zebrafish, a native model organism gene can be replaced by a human gene with the same biological function. After this, mutations can be introduced into the […]
C. elegans is one of the most powerful model organisms and has been used to unravel several key genetic pathways. The C. elegans nematode has been used in parasitology research due to its high genetic tractability as a model organism. Their use in understanding parasitology is considered mainly due to the ease of in vitro culture, short generation […]