The zebrafish is an increasingly popular laboratory organism with many experimental advantages. The animal model has been used by biologists to discover the detailed processes that underlie vertebrate development and disease, and study vertebrate haematopoiesis and immune cell interactions. The zebrafish embryo is also a popular vertebrate model for neurobiology. Zebrafish research, however, is limited […]
Epilepsy Genetics 1 out of 100 persons is living with active epilepsy (Zack and Kobau 2017, WHO 2018). For the subset that can be pinned down to having a genetic cause, there are about 70 or so genes involved in causing the illness (Lindy 2018). Until recently, the frequency of a gene’s association with epilepsy […]
As a service provider, we often use the same technologies/products that we provide to our customers to run experiments in our own lab. Recently, we put our own ScreenChip System to the test. As part of a project for one of our customers, we used CRISPR-Cas9 to generate a complete gene knockout in C. elegans and assessed its effect on pharyngeal pumping. Pharyngeal pumping is […]
Question: What might you get if you cross the feeding organ of a roundworm with a genome wide association study? Answer: A cornucopia of novel genes for synaptic transmission, neuromodulation, energy regulation, peptidergic signaling, learning and memory, and more. This riddle, and its answer, are prompted by the convergence of two exciting trends in research […]
Dr. Andy Golden at NIH discusses his work on identifying regulators and interactors of conserved genes in C. elegans that, when mutated, can cause human disease and opportunities to use C. elegans as a model in clinical and translational research.