Kathleen Conery | The neuromodulator serotonin (5-hydroxytryptamine; 5HT) is often used to stimulate pharyngeal pumping in C. elegans and other nematodes. To investigate the concentration-dependence of 5HT treatment on pump frequency measured in the ScreenChip platform, we tested the effects of 0, 2, 5 and 10 mM 5HT on N2 (wild type) adults.
Kathleen Conery | Most existing anthelmintics act on ion channels or neurotransmitter receptors, so determining whether a candidate compound impairs electrical signaling is useful to know early in the screening process. Essential oil of fennel (Foeniculum vulgare) has been used traditionally in South America as a worming agent against human infections with the trematode parasite, Schistosoma mansoni. Using the ScreenChip platform, we investigated the effect of fennel essential oil as an anthelmintic on C. elegans.
The NemaMetrix ScreenChip platform technology was recognized by the White House as one of the breakthrough life science research technologies. CEO Matt Beaudet spoke with Dr. Robbie Barbero of the US White House Office of Science and Technology Policy, who created a post on the White House website about the promise of new research technologies.
NemaMetrix announces being awarded $249,000 in GAP funding from Oregon Nanoscience and Microtechnologies Institute (ONAMI) to fund “proof-of-concept” work and to fuel development towards commercialization.
NemaMetrix announces being awarded $188,000 for a Phase I Small Business Innovation Research (SBIR) grant from the National Institute of Health. The funds will be used to support fundamental proof of concept research, with an eye towards near-term commercialization, of a microfluidic screening device for health-span extending drugs.