Non-mammalian model organisms are typically used in early research to deliver fast answers to a discovery problem. The most popular model organisms in biological and biomedical research are the fruit fly Drosophila melanogaster, the zebrafish and the nematode C. elegans. We provide a comparison of the advantages and limitations of many commonly used model organisms.
NemaMetrix’s ScreenChip collects live-animal, high-throughput C. elegans electropharyngeograms (EPGs), which are an indication of overall organism health for drug development. Read the blog post on BioCoder published by O’Reilly Bio.
Niemann-Pick Type C is a rare and fatal disorder affecting children. We explore the efficacy of new potential therapeutics with the ScreenChip System.
Serotonin is well known for being important in the regulation of people’s mood. We found that we can model the serotonin biochemical pathway using a sensitive measure for pharyngeal pumping in C. elegans.
C. elegans’ feeding behavior strongly influences the worm’s aging and longevity. We tested adult worms to quantify how aging affects their feeding behavior. In older adults, pharyngeal pumping was weaker and less regular.