Yoanne Clovis, Ph.D. We know that C. elegans’ feeding behavior strongly influences the worm’s aging and longevity1. So, a couple of months ago, we decided to test adult worms from Day 1 to Day 15 to quantify how aging affects their feeding behavior. As expected, we saw that the pumping frequency decreases with age, but [...]
Shawn Lockery, Ph.D. | In C. elegans, a key marker of age-related decline in health is a reduction in the rate of pharyngeal pumping. Until now, it has been necessary to count pumps by eye, which is laborious, slow, and often inaccurate. The NemaMetrix ScreenChip System automates the process of counting pumps by recording their electrical signature, called the electropharyngeogram (EPG). Here we show that the age-related decline in pumping is recapitulated when pumps are counted in electrical recordings.