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C. elegans Screening and Phenomics for Research and Drug Discovery

NemaMetrix is a biotech company based in Eugene, Oregon. Started as a spinout from the University of Oregon, we maintain active collaborations within the academic research community to drive discovery in animal models of human disease. Our core technology integrates microfluidics and electrophysiology to provide biological insights into an important and widely used model organism for human health, C. elegans.

Our flagship product is the ScreenChip System. The ScreenChip System is an automated platform for assaying pharyngeal pumping in C. elegans.  A sensitive measure of the overall health of an organism, pharyngeal pumping and the ScreenChip System excel at revealing phenotypes resulting from genetic mutation and screening for the effects of drug compounds and peptides on well-conserved biological signalling pathways.

Our Most Recent Application Notes

  • Pharyngeal Recordings (EPGs) taken from different species of free-living nematodes

Microfluidic EPG recordings from diverse nematode species

Janis Weeks, Ph.D. | The NemaMetrix ScreenChip system was developed for C. elegans, which is but one of the estimated 1 million members of the highly diverse phylum, Nematoda. To demonstrate the utility of microfluidic EPG recordings from species beyond C. elegans, we adapted the platform to record from several human and animal gastrointestinal parasites, male and female members of a dioecious nematode species, and a carnivorous nematode.

EPG recordings as a new tool for toxicology in C. elegans

Janis Weeks, Ph.D. | The heavy metal, copper (Cu2+), is toxic to humans and C. elegans. We used the ScreenChip system to detect Cu2+ in aqueous samples at concentrations (≤10 mg/L) within the range found in contaminated home water supplies. EPG recordings provide a powerful new tool for C. elegans toxicology research.

  • Physiological Comparison of model organisms commonly used in biomedical research

Worms, Flies or Fish? A Comparison of Common Model Organisms

Yoanne M. Clovis, Ph.D. | Non-mammalian model organisms are typically used in early research to deliver fast answers to a discovery problem. The most popular model organisms in biological and biomedical research are the fruit fly Drosophila melanogaster, the zebrafish and the nematode C. elegans. We provide a comparison of the advantages and limitations of many commonly used model organisms.

Latest News

  • Announcing an L1-stage ScreenChip! Get EPG Recordings from L1 C. elegans.

Announcing a new ScreenChip for L1s

Test EPGs in the L1 stage with the NemaMetrix ScreenChip 10. This device enables researchers to quantitatively study EPG waveforms and phenotypes at an earlier developmental timepoint than has previously been possible.  Specially sized for L1 stage larvae.

  • NemaMetrix Team at the TAGC Conference - July 2016

Visit us July 21-24, 2016 in Wisconsin!

Come and visit our team at the Aging, Metabolism, Pathogenesis, Stress, and Small RNAs in C. elegans conference in Madison, Wisconsin! We'll be showing live demos and discussing the results of our most recent research with the [...]

  • TAGC 2016 Participating Communities

See us at the Allied Genetics Conference!

NemaMetrix will be attending the The Allied Genetics Conference (TAGC) on July 13-17, 2016.  For the first time, researchers studying C. elegans, Drosophila, mouse, zebrafish, yeast, ciliates, and PEQ will be holding meetings under the [...]

Product Applications

PHARMACEUTICAL DRUG DISCOVERY

Our technology provides in vivo results 100 times faster and cheaper than mouse models.

ACADEMIC RESEARCH

Let us help you accelerate the pace of research with our turn-key system.

GLOBAL HEALTH

Searching for an easy anthelmintic screening system? Look no further.

Our Collaborators