C. elegans Screening and Phenomics for Research and Drug Discovery

NemaMetrix is a biotech company based in Eugene, Oregon. Started as a spinout from the University of Oregon, we maintain active collaborations within the academic research community to drive discovery in animal models of human disease. Our core technology integrates microfluidics and electrophysiology to provide biological insights into an important and widely used model organism for human health, C. elegans.

Our flagship product is the ScreenChip System. The ScreenChip System is an automated platform for assaying pharyngeal pumping in C. elegans. A sensitive measure of the overall health of an organism, pharyngeal pumping and the ScreenChip System excel at revealing phenotypes resulting from genetic mutation and screening for the effects of drug compounds and peptides on well-conserved biological signalling pathways.

Our Most Recent Application Notes

  • Mean pump frequency in C elegans - Anandamide and controls.

The Endogenous Cannabinoid Anandamide causes Hyperphagia in C. elegans

Do Nematode Worms get 'The Munchies’? | Shawn Lockery, Ph.D | The NemaMetrix ScreenChip System is a microfluidics platform for recording electropharyngeograms (EPGs) from the nematode worm Caenorhabditis elegans and other nematode species. This technical note demonstrates the utility of the ScreenChip system in pharmacology, taking as an example compounds chemically related to Δ9-tetrahydrocannabinol (THC), the primary psychoactive compound in marijuana (Cannabis sativa).

  • Mutations kqt-1 and kqt-3 and their effects on pharnygeal pumping in C. elegans

KCNQ Potassium Channels and C. elegans Pharyngeal Pumping: A Genetic and Behavioral Model for Cardiac Arrythmia

Yoanne M. Clovis, Ph.D | Humans have over 70 potassium channel genes, but only some of these have been linked to disease. In this respect, the KCNQ family of potassium channels is exceptional: mutations in four out of five KCNQ genes underlie diseases including cardiac arrhythmias, deafness, and epilepsy. In this technical note, we investigated the effect of mutations of orthologous KCNQ-like genes in the nematode C. elegans on electrical excitability using the NemaMetrix ScreenChip System.

Latest News

  • NemaMetrix Team at the TAGC Conference - July 2016

Visit us July 21-24, 2016 in Wisconsin!

Come and visit our team at the Aging, Metabolism, Pathogenesis, Stress, and Small RNAs in C. elegans conference in Madison, Wisconsin! We'll be showing live demos and discussing the results of our most recent research with the [...]

  • TAGC 2016 Participating Communities

See us at the Allied Genetics Conference!

NemaMetrix will be attending the The Allied Genetics Conference (TAGC) on July 13-17, 2016.  For the first time, researchers studying C. elegans, Drosophila, mouse, zebrafish, yeast, ciliates, and PEQ will be holding meetings under the [...]

  • The NemaMetrix Team at the European Worm Meeting in Berlin - 2016

Visit us at the European Worm Meeting in Berlin!

NemaMetrix is pleased to announce that we will be attending the 2016 European Worm Meeting in Berlin on June 1-3, 2016.  Attending a European conference is a unique opportunity for us to hear about the [...]

Product Applications


Our technology provides in vivo results 100 times faster and cheaper than mouse models.


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