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C. elegans Screening and Phenomics for Research and Drug Discovery

NemaMetrix is a biotech company based in Eugene, Oregon. Started as a spinout from the University of Oregon, we maintain active collaborations within the academic research community to drive discovery in animal models of human disease. Our core technology integrates microfluidics and electrophysiology to provide biological insights into an important and widely used model organism for human health, C. elegans.

Our flagship product is the ScreenChip System. The ScreenChip System is an automated platform for assaying pharyngeal pumping in C. elegans. A sensitive measure of the overall health of an organism, pharyngeal pumping and the ScreenChip System excel at revealing phenotypes resulting from genetic mutation and screening for the effects of drug compounds and peptides on well-conserved biological signalling pathways.

Our Most Recent Application Notes

  • Mutations kqt-1 and kqt-3 and their effects on pharnygeal pumping in C. elegans

KCNQ Potassium Channels and C. elegans Pharyngeal Pumping: A Genetic and Behavioral Model for Cardiac Arrythmia

Download as PDF Background Humans have over 70 potassium channel genes, but only some of these have been linked to disease. In this respect, the KCNQ family of potassium channels is exceptional: mutations in four out of [...]

  • Alzheimer's Phenotype displays change in Pharygeal pumping activity

Microfluidic EPG Recordings Show Striking Pharyngeal Pumping Phenotype in a C. elegans Alzheimer’s Disease Model

Preliminary Findings Download as PDF   Fig. 1: CL4176: smg-1(cc546) I; dvIs27 X.dvIs27[pAF29(myo-3/Aβ1-42/let UTR)+pRF4(rol-6(su1006))] CL802: smg-1(cc546) I; rol-6(su1006) II     Strain CL4176 accumulates amyloid-β1-42 in body wall muscles after shifting from 15o [...]

  • Trehalose extends healthspan in C. elegans over time

Trehalose Extends Healthspan in C. elegans

Preliminary Findings Download as PDF       Adults were reared and tested in M9 medium plus 5 mM trehalose, which has previously been shown to extend lifespan in C. elegans (Honda et al. , [...]

Latest News

  • NemaMetrix Team at the TAGC Conference - July 2016

Visit us July 21-24, 2016 in Wisconsin!

Come and visit our team at the Aging, Metabolism, Pathogenesis, Stress, and Small RNAs in C. elegans conference in Madison, Wisconsin! We'll be showing live demos and discussing the results of our most recent research with the [...]

  • TAGC 2016 Participating Communities

See us at the Allied Genetics Conference!

NemaMetrix will be attending the The Allied Genetics Conference (TAGC) on July 13-17, 2016.  For the first time, researchers studying C. elegans, Drosophila, mouse, zebrafish, yeast, ciliates, and PEQ will be holding meetings under the [...]

  • The NemaMetrix Team at the European Worm Meeting in Berlin - 2016

Visit us at the European Worm Meeting in Berlin!

NemaMetrix is pleased to announce that we will be attending the 2016 European Worm Meeting in Berlin on June 1-3, 2016.  Attending a European conference is a unique opportunity for us to hear about the [...]

Product Applications

PHARMACEUTICAL DRUG DISCOVERY

Our technology provides in vivo results 100 times faster and cheaper than mouse models.

ACADEMIC RESEARCH

Let us help you accelerate the pace of research with our turn-key system.

GLOBAL HEALTH

Searching for an easy anthelmintic screening system? Look no further.

Our Collaborators