C. elegans Screening and Phenomics for Research and Drug Discovery
NemaMetrix is a biotech company based in Eugene, Oregon. Started as a spinout from the University of Oregon, we maintain active collaborations within the academic research community to drive discovery in animal models of human disease. Our core technology integrates microfluidics and electrophysiology to provide biological insights into an important and widely used model organism for human health, C. elegans.
Our flagship product is the ScreenChip System. The ScreenChip System is an automated platform for assaying pharyngeal pumping in C. elegans. A sensitive measure of the overall health of an organism, pharyngeal pumping and the ScreenChip System excel at revealing phenotypes resulting from genetic mutation and screening for the effects of drug compounds and peptides on well-conserved biological signalling pathways.
Our Most Recent Application Notes
PHENOTYPIC ANALYSIS OF C. ELEGANS MUTANTS
The NemaMetrix ScreenChip System is a microfluidic platform for recording electro-pharyngeograms (EPGs) from Caenorhabditis elegans and other nematode species. This technical note demonstrates that the pharyngeal phenotypes of the previously identified neurotransmission mutants eat-4 (1) and avr-15 (2) are recapitulated in the ScreenChip system.
E. COLI-INDUCED PHARYNGEAL PUMPING IN C. ELEGANS USING THE SCREENCHIP
Pharyngeal pumping behavior in C. elegans is employed to ingest bacteria, the worms’ normal food. Under laboratory conditions, C. elegans are reared on agar plates seeded with the E. coli strain OP50, which stimulates feeding behavior (1, 2). Accordingly, we tested the ability of OP50 treatment to elicit pharyngeal pumping, using the ScreenChip system.
SEROTONIN-INDUCED PHARYNGEAL PUMPING IN C. ELEGANS
The neuromodulator serotonin (5-hydroxytryptamine; 5HT) is often used to stimulate pharyngeal pumping in C. elegans and other nematodes (e.g., 1,2,3). To investigate the concentration-dependence of 5HT treatment on pump frequency measured in the ScreenChip platform, we tested the effects of 0, 2, 5 and 10 mM 5HT on N2 (wild type) adults on Day 1.
NemaMetrix will be attending the The Allied Genetics Conference (TAGC) on July 13-17, 2016. For the first time, researchers studying C. elegans, Drosophila, mouse, zebrafish, yeast, ciliates, and PEQ will be holding meetings under the [...]
NemaMetrix is pleased to announce that we will be attending the 2016 European Worm Meeting in Berlin on June 1-3, 2016. Attending a European conference is a unique opportunity for us to hear about the [...]
Mike Harris working with the NemaMetrix ScreenChip system during a customer workshop. At our inaugural ScreenChip Workshop, one of our very first customers, Dr. Mike Harris, had a burning question. He'd been collaborating for years on [...]
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